Depression affects an estimated 25 to 40% of people with terminal illness, yet it is significantly undertreated in palliative care settings
End-of-Life Distress Treatment in La Crosse, WI: Support for the Whole Person, Not Just the Body
A terminal diagnosis changes everything. The fear, grief, depression, and existential suffering that come with it deserve the same serious clinical attention as physical symptoms. IV ketamine therapy and Spravato offer rapid, meaningful relief for the psychological suffering that too often goes undertreated at the end of life.
The Time You Have Matters. You Deserve to Spend It With Less Suffering.
Depression and anxiety affect up to 40% of people with terminal illness. For many of them, that psychological suffering is undertreated or left entirely unaddressed, while medical care focuses on physical symptoms and comfort. But the fear of dying, the grief of anticipated loss, the sense of unfinished business, and the existential questioning that a terminal diagnosis brings are not secondary concerns. They are central to the quality of the time that remains.
At Relevate Ketafusion, we believe every person facing the end of life deserves compassionate, effective treatment for psychological suffering. IV ketamine therapy and Spravato work on the brain’s glutamate system, producing rapid relief from depression and anxiety that standard antidepressants, which require weeks to build up, simply can’t offer when time is limited. Research on ketamine in hospice and palliative care settings has shown meaningful improvement in depression and anxiety within days.
We approach this work with the deepest respect for the dignity, autonomy, and humanity of every person who comes to us. This isn’t about extending life. It’s about the quality of the life that’s here.


Understanding End-of-Life Distress: More Than Sadness About Dying
End-of-life distress encompasses the full range of psychological and existential suffering that accompanies terminal illness. It includes clinical depression and anxiety, which are medical conditions deserving medical treatment. It includes existential suffering: the confrontation with mortality, the loss of identity and independence, unresolved relationships, and the search for meaning in the face of death. And it includes anticipatory grief, both the dying person’s grief for their own life and the grief of those who love them.
This suffering is not inevitable. It is not simply the natural consequence of dying that must be endured. Depression at the end of life responds to treatment. Anxiety can be relieved. The quality of consciousness and emotional experience during the final weeks and months of life can be profoundly improved with appropriate care. That is the work we do.
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Types of End-of-Life Distress We Can Help With
End-of-life distress takes many forms, and the clinical conditions it produces are treatable. Here's where ketamine therapy and Spravato can offer meaningful support.
Depression Related to Terminal Illness
Clinical depression in the context of terminal illness is not simply appropriate sadness. It is a distinct medical condition that reduces quality of life, undermines the ability to make meaningful decisions, and increases physical symptom burden. It also responds to treatment. Ketamine therapy's rapid onset makes it particularly well-suited to the palliative care context, where the weeks required for standard antidepressants to take effect represent a significant proportion of remaining life.
Anxiety and Fear of Dying
Fear of the dying process, fear of pain, fear of loss of control, and anticipatory anxiety about what comes after are among the most common and distressing features of terminal illness. These are not irrational fears to be talked out of. They are neurological responses to profound threat that respond to neurological treatment. Ketamine's rapid calming effect on overactive anxiety circuits can provide meaningful relief that allows patients to engage more fully with the time they have.
Existential Distress and Demoralization
Demoralization, a state of hopelessness, helplessness, and loss of meaning distinct from but often co-occurring with clinical depression, is particularly common at end of life. Ketamine therapy has been associated with profound shifts in perspective and a renewed sense of connection and meaning in research settings, particularly in palliative care. While we approach these outcomes with appropriate scientific humility, the clinical evidence is compelling enough to offer ketamine as a meaningful option for existential distress.
Depression and Anxiety in Family Members and Caregivers
End-of-life distress doesn't belong only to the person who is dying. Family members and caregivers experiencing severe depression, anxiety, or anticipatory grief in the context of a loved one's terminal illness are also candidates for ketamine therapy and Spravato. The suffering of caregivers is real, clinically significant, and deserving of treatment.
Depression with Suicidal Ideation in Terminal Illness
Suicidal ideation in the context of terminal illness requires careful clinical distinction between a wish to hasten death due to uncontrolled suffering, which is a treatable symptom, and a considered, autonomous end-of-life decision. For patients whose suicidal ideation reflects treatable depression or anxiety rather than a settled autonomous choice, Spravato's FDA approval for MDD with active suicidal ideation makes it a directly indicated, fast-acting option. If you or someone you love is in crisis, please call or text 988.
Your Treatment Journey at Relevate Ketafusion
We adapt every aspect of the treatment journey to your needs and circumstances. For patients navigating terminal illness, that means flexibility, compassion, and honesty at every step.
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Initial Consultation
Your journey starts with a virtual consultation. We'll talk through your diagnosis, your current psychological symptoms, your goals for treatment, and any physical limitations that affect your ability to participate. We'll be honest about what ketamine therapy can realistically offer, and we'll help you make an informed decision with full context. The virtual format means you can have this conversation from home, wherever you're most comfortable.
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Personalized Treatment Plan
We build your plan around your specific situation, physical condition, prognosis, and goals. For end-of-life patients, this means being realistic about what treatment looks like given your circumstances, coordinating with your palliative care or hospice team where appropriate, and focusing on the most meaningful improvements in quality of life within your timeline.
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Treatment Sessions
Every session takes place in a private, calm treatment room with ambient lighting and soothing music. Our medical team stays present throughout, monitoring your vitals and your comfort in real time. We bring particular attentiveness to the comfort and dignity of every patient, and especially to those for whom this treatment takes place in the context of profound personal significance. Plan to have someone drive you home afterward.
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Ongoing Support and Monitoring
We track your response and adjust the plan as needed. Our goal is meaningful improvement in psychological wellbeing and quality of life, and we measure that in ways that are realistic and relevant to your circumstances. We work collaboratively with your broader care team and adapt our approach as your situation evolves.
Our Treatments: IV Ketamine and Spravato
We offer two clinically validated, rapid-acting treatments for the depression, anxiety, and existential distress of terminal illness. Your provider will help determine the right fit based on your diagnosis, prognosis, physical condition, and goals.
IV Ketamine Therapy
Administered directly into the bloodstream through a small IV line, ketamine infusions offer precise dosing and immediate effect. Sessions typically last 40 to 60 minutes in a private, calm treatment room with continuous medical supervision. Research on ketamine in palliative care settings, including a published study of ketamine in hospice patients, has shown meaningful improvement in depression and anxiety within days of treatment. This rapid onset is particularly important when time is a factor. IV ketamine is self-pay and not covered by insurance.
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Spravato (Esketamine) Therapy
FDA-approved for treatment-resistant depression and MDD with suicidal ideation, Spravato offers a well-validated option for end-of-life depression that hasn't responded to conventional antidepressants. You self-administer the nasal spray in our clinic under direct medical supervision, followed by a required monitoring period. Sessions last approximately two hours. Spravato is covered by most major insurance plans, and our team handles verification and prior authorization before your first visit.
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The Science Behind Ketamine for End-of-Life Distress
Depression and anxiety at the end of life involve the same neurological mechanisms as depression and anxiety in any other context: dysregulation of neural circuits responsible for mood, threat detection, and the ability to find meaning and connection. Standard antidepressants address these circuits through serotonin, over a timeline of weeks. Ketamine and Spravato take a different route.
By acting on glutamate and NMDA receptors, both treatments trigger rapid synaptic growth and neural plasticity, producing meaningful improvements in mood and anxiety within hours to days. In the palliative care context, where weeks are a luxury that many patients don’t have, this timeline is not just convenient. It’s clinically essential.
A published open-label study of daily oral ketamine for depression and anxiety in hospice patients demonstrated meaningful improvement within 28 days of treatment, with a good safety profile. IV ketamine’s more precise dosing and rapid onset make it potentially even more effective in this population. The research is still developing, but what exists offers genuine clinical encouragement.

Why Choose Relevate Ketafusion for End-of-Life Distress
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Rapid Relief When Time Is the Most Precious Thing
Both IV ketamine and Spravato produce meaningful results within hours to days rather than weeks. In the context of terminal illness, that timeline isn’t a feature. It’s the whole point. We understand the urgency of this situation and we approach it accordingly.
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Care That Honors the Whole Person
We treat every person facing end-of-life distress with profound respect for their dignity, autonomy, and humanity. This is not routine care. We know that, and we show up for it accordingly. Every member of our team approaches this work as a privilege.
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The Only IV Ketamine Clinic in the Coulee Region
Relevate Ketafusion is the only provider in the La Crosse area offering IV ketamine infusions. The nearest alternative is over two hours away. For someone whose energy and mobility are limited by illness, that distance is a real barrier. We built this clinic to eliminate it.
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Spravato Covered by Insurance
Spravato is covered by most major insurance plans for treatment-resistant depression. Our team verifies your coverage before your first session and handles prior authorization. For IV ketamine, transparent self-pay pricing is available with HSA/FSA acceptance and CareCredit financing.
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A Medical Team With the Depth This Work Requires
Dr. Schumaker’s emergency medicine background means he has sat with people in their most profound moments of crisis and vulnerability throughout his career. Lisa Knudtson’s experience with trauma and loss, Robyn Brown’s personal understanding of anxiety and suffering, and Tina Schumaker’s own journey through darkness and toward healing all shape how this clinic approaches the most serious human experiences.
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Founded by Someone Who Understands What It Means to Find Light in a Dark Place
Tina Schumaker built Relevate after her own experience with treatment-resistant depression and PTSD. She knows what it means to be in a place where hope feels impossible, and what it feels like when something finally works. That experience is the foundation of how this clinic cares for people at every stage of life, including its final chapter.
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