Research
While ketamine’s status as a generic medication has limited traditional pharmaceutical funding, its remarkable therapeutic potential has sparked extensive independent research by physicians worldwide. Below are select peer-reviewed studies highlighting ketamine’s effectiveness in mental health treatment.
Ketamine for the treatment of mental health and substance use disorders: comprehensive systematic review
In the past two decades, subanaesthetic doses of ketamine have been demonstrated to have rapid and sustained antidepressant effects, and accumulating research has demonstrated ketamine’s therapeutic effects for a range of psychiatric conditions.
Ketamine treatment for depression: a review
This manuscript reviews the clinical evidence regarding single-dose intravenous (IV) administration of the novel glutamatergic modulator racemic (R,S)-ketamine (hereafter referred to as ketamine) as well as its S-enantiomer, intranasal esketamine, for the treatment of major depressive disorder (MDD).
An Assessment of the Anti-Fatigue Effects of Ketamine from a Double-Blind, Placebo-Controlled, Crossover Study in Bipolar Disorder
Fatigue is a multidimensional condition that is difficult to treat with standard monoaminergic antidepressants. Ketamine, an N-methyl-D-aspartate receptor (NMDAR) antagonist produces rapid and robust improvements in depressive symptoms in treatment-resistant depression.
Ketamine-Assisted Group Psychotherapy for Frontline Healthcare Workers with COVID-19-Related Burnout and PTSD: A Case Series of Effectiveness / Safety for 10 Participants
This study reports on 10 frontline healthcare workers, employed during the COVID-19 pandemic and experiencing symptoms of burnout and PTSD, treated with group ketamine-assisted psychotherapy (KAP) in a private outpatient clinic setting. Participants attended 6 sessions once weekly.